The End of Alzheimer's

The End of Alzheimer's

The First Program to Prevent and Reverse Cognitive Decline

Book - 2017
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Penguin Putnam
The instant New York Times and Wall Street Journal bestseller

A groundbreaking plan to prevent and reverse Alzheimer&;s Disease that fundamentally changes how we understand cognitive decline.

Everyone knows someone who has survived cancer, but until now no one knows anyone who has survived Alzheimer's Disease. 
In this paradigm shifting book, Dale Bredesen, MD, offers real hope to anyone looking to prevent and even reverse Alzheimer's Disease and cognitive decline.  Revealing that AD is not one condition, as it is currently treated, but three, The End of Alzheimer&;s outlines 36 metabolic factors (micronutrients, hormone levels, sleep) that can trigger "downsizing" in the brain. The protocol shows us how to rebalance these factors using lifestyle modifications like taking B12, eliminating gluten, or improving oral hygiene.
The results are impressive. Of the first ten patients on the protocol, nine displayed significant improvement with 3-6 months; since then the protocol has yielded similar results with hundreds more. Now, The End of Alzheimer&;s brings new hope to a broad audience of patients, caregivers, physicians, and treatment centers with a fascinating look inside the science and a complete step-by-step plan that fundamentally changes how we treat and even think about AD.

Baker & Taylor
Draws on scientific research and clinical results to outline a groundbreaking plan to prevent and reverse Alzheimer's Disease and cognitive decline through strategic lifestyle modifications designed to address specific contributing metabolic imbalances.

Publisher: New York : Avery, an imprint of Penguin Random House, [2017]
ISBN: 9780735216204
Branch Call Number: 616.8311 BR
Characteristics: 308 pages : illustrations ; 24 cm


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VaughanPLGraeme Oct 05, 2019

Overall, I found this to be a very frustrating book. I would love to believe there's a program that can reliably prevent or reverse the cognitive decline seen in Alzheimer's disease, but I think it’s irresponsible for the author to make the claims he does based on the evidence in the book and his published research. No rigorous, controlled trial of this program has yet been published in a peer-reviewed journal; only case studies of patients on this protocol have been published so far, which is not sufficient evidence to make the bold claims in the book. I was shocked to realize that when the book was published, case reports on only 19 patients had been published. A study reporting 100 cases was later published, but even that is a small number by the standards of clinical research on a common disease.

The lifestyle changes promoted in the book seem, for the most part, to be pretty reasonable suggestions in terms of improving overall health. There doesn’t seem to be good evidence for many of the specifics of the dietary recommendations, but the plan does recommend eating primarily whole foods (rather than processed foods), lots of a variety of vegetables, and very little sugar, which is hard to argue against as general dietary guidelines. The exercise and sleep recommendations in the book also seem reasonable and could help a lot of people improve their overall health and possibly reduce the likelihood of developing Alzheimer's disease.

However, in addition to the lifestyle guidelines promoted in the book, the "basic plan" includes taking some combination of the following: MCT oil, curcumin, Ashwagandha, Bacopa monnieri, Gotu kola, magnesium threonate, ubiquinol, PQQ, resveratrol, nicotinamide riboside, DHA and EPA, liposomal glutathione, probiotics and prebiotics, vitamins D and K2, mixed tocopherols and tocotrienols, "specialized pro-resolving mediators", methylcobalamin, methylfolate, P5P, alpha-lipoic acid, N-acetylcysteine, cinnamon, berberine, zinc picolinate, manganese, vitamin C, SAM-e or folate, and huperzine A. Until a large, randomized trial is done with placebos for these supplements, I'll be skeptical of their value in the prevention or treatment of Alzheimer's disease.

I would note that the author of this book presumably has a significant financial interest in promoting this program. As I write this review, people can sign up for the "ReCODE" program for $1399 (US) and this includes lab tests, genome analysis, various reports, and tailored recommendations for lifestyle changes, nutrition, and supplementation. There’s also a monthly subscription plan that provides additional services for $75 a month with a minimum commitment of one year. These costs do not seem to include any of the recommended supplements.

The fact that Dr. Bredesen appears to have a financial stake in these programs certainly doesn't mean he's only in it for the money. I'm sure he believes the program works, at least for some patients, but I'm always skeptical when people sell books promoting expensive, unproven treatments in which they have a financial interest. Many people with dementia and their caregivers are desperate for any treatment that will give them hope and I worry they will spend large amounts of money on a treatment protocol that may do nothing for them or perhaps even cause harm, which also can't be ruled out without a proper trial.

In a recent publication, Dr. Bredesen and his team expressed interest in doing a prospective, randomized, controlled clinical trial. I truly hope that happens and if it does, I certainly hope it is successful. However, until a proper trial is done, I’ll be skeptical there's any real value in the recommendations in this book, aside from general advice to do things most people already know they should: exercise regularly, get enough sleep, and eat a balanced diet of mostly whole foods.

Aug 13, 2019

Excellent work by Dr Bredesen providing proof and hope that a disease such as Alzheimer's is in fact treatable. It may not be the whole picture or work for everyone exactly as he lays out but we would all be very wise to look as his protocol, diet and supplement suggestion with much seriousness. For anyone who has been through it they know Alzheimer's is an awful disease that steals life from the whole family, friends and caregivers. Conventional doctors don't help and often make circumstances worse. In 30 years, with the groundbreaking work of Dr Bredesen and others in this field, I believe we will look back on how Alzheimer's patients were treated conventionally with many regrets.

May 09, 2019

I was amazed to learn of the existence of this book and the suggestion that there was a way to actually prevent and cure this debilitating disease. It’s a multi-pronged process, and the author gives case histories showing that it works. Everyone can benefit by reading the tips provided. So much suffering can be avoided! It wasn’t always easy reading, sometimes favouring a lot of medical jargon, which is probably why there is a companion summary volume that might be helpful for many. Nevertheless an important and worthwhile work.

Oct 16, 2018

Alas, if you check Dr.Bredsen's references , he is basing his theory on his one paper with a mere 10 cases. He admits academic review boards refused to okay his protocol. If you examine his 36 metabolic factors,then his complex treatment protocol, there is no way to prove that the protocol accounts for alleged benefits, independent of exercise, healthy diet, quality sleep and mental exercises.In other words, although a medical scientist by training, his bias for his theory means he has no comparison group ( randomized controlled research trial). By proposing such a complicated protocol, no other medical researcher will be able to validate or disprove his theory. So again with unproven, "medical" pseudoscience medical ,caveat emptor or buyer beware.

Dec 16, 2017

This is a brave book, based on decades of careful work and clinical success with clients. The author is going against the medical establishment that relies almost completely on prescription medicine. The author proposes a prudent evaluation, followed by corrections to diet, lifestyle, and addition of supplements.

Bredesen has shown that the approach works. Nothing else has ever worked. Hence this is one of the most important books you may ever read!

Nov 26, 2017

I read a lot of nonfiction books per year. And, many of them are very informative and interesting. But, this one is among the ones on top of my list in terms of its impact at the individual and societal levels.

This book is bound to be a boon for genetic testing (23andMe, etc.).

Before Bredesen’s protocol to treatAlzheimer’s disease (AD) no one had much interest in taking a genetic test that would divulge that one is at a very high risk of a disease that is truly irreversible. Such a finding would be devastating for the individual and his close family.

Now, in our new post-Bredesen era the above proposition is obsolete. And, genetic tests are now immensely valuable. That is because they inform one of their respective and potential high risk for a disease that is fully reversible if addressed reasonably early. Given that, one is far better knowing what could happen down the road and taking all the measures to prevent the onset or development of AD.

I read this book right after reading “The Plant Paradox” by Steven Gundry, another formidable book. I am glad I read these two books consecutively. This is because the nutrition guidelines imparted by both doctors are for the most part consistent with each other. That is even though Gundry is really focused on overall health. Meanwhile, Bredesen is exclusively focused on the prevention and reversal of AD. However, it is clear that whatever is good for your brain and for preventing AD is very much good for everything else.

Bredesen’s understanding of AD is second to none. His taxonomy of the three different types of AD is really original and interesting. The three AD types include:
Type 1 triggered by inflammation due to excess simple carbohydrate intake (sugars). It is associated with insulin resistance, diabetes. It typically hits people in their 60s;
Type 2 is due to inadequate neurotropic support of the brain. It is associated with a deficiency in hormones (including Thyroid and gender-related hormones). It typically hits one in their 70s; and
Type 3 is toxin related AD. It often hits people earlier in their 50s. It is triggered by poisonous substances like Mercury, arsenic, or germs like Lyme disease, mold, or toxic bacteria.

Fairly early in the book, Bredesen explains in detail what AD is. At its essence. AD occurs when an enzyme, Protease, cuts a protein, Amyloid Precursor Protein (APP), into four fragments instead of just two. When cut into four fragments, the modified APP will cause Amyloid formation within the brain. And, will eventually cause synaptic loss and synaptic cell death resulting in AD. When instead, Protease cuts APP into just two fragments, it will support synaptic formation and prevent AD.

Bredesen’s protocol (ReCODE) can reverse all three types of AD. And, it relies mainly on nutrition, lifestyle changes, and supplements. He has developed and tested his protocol on hundreds of patients. Most of the success stories make for really impressive narrative.

The last chapter in the book is really interesting. Here Bredesen reveals the resistance he has encountered from the medical establishment that still wants to believe that AD is entirely not reversible. And, that nutrition can’t possibly cure this disease. The chapter starts with a famous quote from Max Planck (one of the fathers of quantum mechanics) that says it all: “Science advances one funeral at a time.”

Nov 25, 2017

Bredesen has done a nice job with this book, bringing together a larger and more comprehensive range of things to do to improve cognitive function than any other authors I have read on this subject.
However I fear that for many, his approach will be LESS beneficial than some of the simpler plans because he suggests SO MUCH without properly emphasizing THE ONE THING that is common to virtually all the clinical evidence of reversal -- so those reading his book, might be overwhelmed with just how much he suggests and decide to do some but not all -- and inadvertently omit doing what does appear to be the most critical part for most success:
On page 180 he says: "This is a largely plant-based diet with an emphasis on vegetables, especially non-starchy ones...some fish, poultry and meat are fine, but remember that meat is a condiment." But he doesn't emphasize this enough in the book -- although when I read his published paper some months ago, it was clear that his patients that were improving WERE getting well coached to cut way back on their eating of animal foods. But his book doesn't do such a good job of explaining how important this aspect is.
In fact judging by the endorsements on his book -- which includes many folks well known for their outspoken negative criticisms of plant-based diets, lots of educated intelligent people are failing to see that the "plant-based" part of his program is critical. The science does pretty strongly suggest -- that consuming any more than tiny amounts of animal protein, clearly does INCREASE risk of diabetes, heart disease, inflammation, and blood pressure -- all of which are drivers of dementia.
Because his program includes many other things that are well supported in the published literature (like fasting from dinner to breakfast, exercise, and B-12 supplementation) as long as people in fact do keep their animal consumption very low (or better yet eliminate it!) , they are likely to see some benefit from this program, however I think many are likely to focus upon the less important parts of his program, and overlook this most critical part --- that is why I prefer, "The Alzheimer's Solution". That book is much simpler to follow and implement and does it make it very clear that a plant-based diet and exercise is THE foundation of reversing cognitive decline. I'd suggest reading that book (Alzheimer's Solution) FIRST -- then if you are able and wanting to put icing on the cake, and maybe get a bit more benefit, you can add the other components that Bredesen suggests. But we now have so much science linking meat/dairy/eggs with diabetes, high blood pressure, CVD, inflammation and more...that to fail to address the harms from these items, will probably keep people from seeing results.

Oct 04, 2017

The author, UCLA medical research faculty and founding CEO of the Buck Institute for Research on Aging, claims in this clearly-written summary of decades of research that Alzheimer's Disease may in fact be beatable in some cases. Bredensen's research suggests that AD is not a brain failure, but rather a hyper-over-reaction to toxins, lack of nutrients, and inflammation. Thus, he has developed an approach to treatment which involves up to 36 facets of one's overall health, an approach that is not treatment by a single drug but rather a personalized *set* of treatments in the areas of diet and nutrition, physical activity, stress reduction and sleep hygene. The resulting protocols are holistic, and multi-modal, comparable to Ayurvedic or traditional Chinese medicine (even involving meditation). And the radical news is that he claims hundreds of success stories preventing, or even reversing, cognitive decline.
I for one sincerely and deeply hope he is right!


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Jun 10, 2019

pink_dolphin_3025 thinks this title is suitable for 8 years and over


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Jun 10, 2019

This book is a book for people of many ages, ranging from children to seniors, as to learn about a disease called Alzheimer's disease, how to reverse it, and how to prevent themselves from getting it in the future.
Ever since I heard about this disease a few months ago, I've found this wonderful book. A must read!


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